ALTHOUGH the iodides have been employed in the treatment of syphilis since 1821, their mode of action has been obscure. Clinical experience has shown that they have little or no therapeutic effect in the early stages of the disease, this fact being due, it is commonly stated, to the absence of spirocheticidal activity. Thus Tomasczewski1 in 1910 reported that potassium iodide had no prophylactic or curative activity in the treatment of experimental syphilis of monkeys and rabbits. Nichols2 also reported that single intravenous injections of potassium iodide in doses of 0.01 and 0.03 Gm. per kilogram of body weight were ineffective in the treatment of 3 rabbits with acute testicular syphilis, although the intramuscular injection of 1 Gm. per kilogram into a fourth animal resulted in evidences of spirocheticidal activity. At the same time, however, Neisser3 reported that it was possible to prevent the development of
KOLMER JA. PENICILLIN IN THE TREATMENT OF EXPERIMENTAL SYPHILIS OF RABBITS: V. The Synergistic or Additive Activity of Penicillin Injected Intramuscularly with Sodium Iodide Administered Orally and Intravenously. Arch Derm Syphilol. 1950;61(1):49–55. doi:10.1001/archderm.1950.01530080055005
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