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January 1950

PENICILLIN IN THE TREATMENT OF EXPERIMENTAL SYPHILIS OF RABBITS: VI. The Synergistic or Additive Activity of Penicillin Injected Intramuscularly and Tryparsamide Administered Intravenously

Author Affiliations

Professor of Medicine, Temple University School of Medicine and School of Dentistry; Director of the Research Institute of Cutaneous Medicine With the Technical Assistance of ANNA M. RULE PHILADELPHIA

From the Research Institute of Cutaneous Medicine.

Arch Derm Syphilol. 1950;61(1):56-62. doi:10.1001/archderm.1950.01530080062006

In 1919 Brown and Pearce 1 reported that tryparsamide, the sodium salt of p-N-phenylglycineamidoarsonic acid, was effective in the treatment of experimental syphilis of rabbits when administered by intravenous injection in single doses of 0.4 to 0.5 Gm. per kilogram of body weight. This statement was based on the observation of negative results on dark field examinations for Treponema pallidum after the administration of the compound, along with healing of the testicular lesions and the absence of recurrent infections, although transfers of lymph nodes to fresh animals as a test for complete or biologic cure were not conducted. The maximal single tolerated dose for rabbits by intravenous injection was from 0.75 and 1.0 Gm. per kilogram,2 so that the chemotherapeutic index of tryparsamide has been stated to be about 2. The results of our experiments, reported herewith, have shown that the maximal single tolerated dose for rabbits by

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