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Article
February 1950

TREATMENT OF SYPHILIS WITH AUREOMYCIN ADMINISTERED BY MOUTH

Author Affiliations

ROCHESTER, MINN.

From the Section on Dermatology and Syphilology (Dr. Kierland and Dr. O'Leary) and the Division of Medicine (Dr. Herrell), Mayo Clinic.

Arch Derm Syphilol. 1950;61(2):185-195. doi:10.1001/archderm.1950.01530090015003
Abstract

WHAT MIGHT be called the "antibiotic era" of syphilotherapy began with the introduction of penicillin in the treatment of syphilis. Naturally, therefore, antibiotics developed since the introduction of penicillin also have been examined for their possible value in the treatment of syphilis. The new antibiotic aureomycin appears to have a wide range of antibacterial activity. The present report is concerned with an expansion of our previously reported investigations on its oral use in the treatment of syphilis.

It was evident from the report by Heilman1 that aureomycin possesses antispirochetal activity which is greater than that of penicillin against experimental infectious relapsing fever and leptospirosis icterohaemorrhagica. His observations led us to administer aureomycin orally to patients with early infectious syphilis2 and to patients with late cutaneous syphilis and neurosyphilis3. The results obtained showed that aureomycin has definite antisyphilitic activity when administered by

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