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February 1950

TREATMENT OF EARLY SYPHILIS WITH PENICILLIN AND BISMUTH SUBSALICYLATE: Daily Injection of 500,000 Units of Penicillin G in Sodium Chloride Solution for Twenty Consecutive Days and Ten to Twenty Doses of Bismuth Subsalicylate at the Rate of Two a Week

Author Affiliations


From the Department of Dermatology and Syphilology, University of Habana, Medical School, service of Dr. V. Pardo-Castello.

Arch Derm Syphilol. 1950;61(2):196-209. doi:10.1001/archderm.1950.01530090026004

THE PURPOSE of this paper is to show that constant hemoconcentrations of penicillin do not seem to be essential in the treatment of syphilis and that penicillin dissolved in sodium chloride solution and injected intramuscularly once a day appears to act as effectively in early syphilis as does penicillin in absorption-delaying menstruums.

Treatment of syphilis with penicillin must be made easy and not too expensive for the average patient. Injections every two or three hours cannot be used for the large mass of people suffering from syphilis, since hospitalization is required. Penicillin in absorption-retarding menstruums was therefore devised so that one or, at the most, two injections a day would be used; however, penicillin in oil and wax produced a high percentage of allergic reactions, some of them of such a severe type that patients refused further treatment. Penicillin in other vehicles as well as in chemical