A COMBINATION of penicillin injected intramuscularly and oxophenarsine hydrochloride (mapharsen®) administered intravenously has shown pronounced synergistic or additive effects in the chemotherapy of acute syphilitic orchitis of rabbits.1 Similar results have been observed in combined treatment with penicillin and bismuth compounds administered intramuscularly.2 Synergistic or additive effects have been observed also in combined treatment with penicillin given orally and oxophenarsine hydrochloride injected intravenously and intramuscularly and bismuth subsalicylate administered intramuscularly,3 as they have been seen, likewise, in combined treatment with penicillin given by intramuscular injection and sodium iodide administered by oral and intravenous routes.4 Since, however, combined treatment with penicillin injected intramuscularly and tryparsamide administered intravenously has shown much less evidence of synergistic or additive chemotherapeutic effects,5 we have thought it advisable to determine whether or not combined treatment with bismuth compounds given by intramuscular injection and tryparsamide administered
KOLMER JA, RULE AM. TRYPARSAMIDE AND BISMUTH SUBSALICYLATE IN THE TREATMENT OF EXPERIMENTAL SYPHILIS OF RABBITS: Synergistic or Additive Activity. Arch Derm Syphilol. 1950;61(2):271–275. doi:10.1001/archderm.1950.01530090101009
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