THE ANTIHISTAMINIC drugs, while new, have already been found to be useful adjuncts in the therapy of many pruritic cutaneous diseases. These agents are usually administered by the oral route or by topical application. Iontophoresis has been utilized with equivocal results, and the intravenous route is not commonly employed. Subjectively, the patient often experiences relief from pruritus, and, objectively, the eruption may be favorably influenced. The study here with reported includes the results obtained after the administration at different times of eight antihistaminic preparations by mouth and seven by topical application in treatment of a wide range of pruritic dermatoses with the object of assaying the limits of usefulness of these drugs in allergic and some nonallergic dermatoses. A comparison is made of the relative efficiency of the available drugs and the preferable medium for their administration. The incidence of untoward reactions is also catalogued.
HISTORY OF THE ANTIHISTAMINIC DRUGS
WALDRIFF GA, DAVIS J, LEWIS GM. ANTIHISTAMINIC DRUGS IN DERMATOLOGIC THERAPY. Arch Derm Syphilol. 1950;61(3):361–378. doi:10.1001/archderm.1950.01530100005001
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