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Article
March 1950

PENTAVALENT ARSENIC COMPOUNDS IN TREATMENT OF PEMPHIGUS

Arch Derm Syphilol. 1950;61(3):500-501. doi:10.1001/archderm.1950.01530100144026
Abstract

It was with much interest and gratification that we read of the use of carbarsone in the treatment of pemphigus as suggested by Little in 19451 and reported by Combes in the Society Transactions of the Archives in March 1948.2

We always felt that preparations containing pentavalent arsenic have definite value in the therapeutic regimen of pemphigus. One of us (M. O.) introduced this treatment with acetarsone and reported his first observations in 1927.3 This therapy was accepted by many dermatologists, including Kromayer, who also claimed benefit from the drug in 6 cases.4

In 1943 we reported the use of acetarsone for 3 patients who were alive at the time of writing without any evidence of the disease.5 Their cases along with others were presented at the Chicago Dermatological Society.6

That failures occur with this form of treatment is, of course, well known.

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