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Article
April 1950

CLINICAL EVALUATION OF PHENINDAMINE (THEPHORIN®) OINTMENT FOR RELIEF OF ITCHING: Preliminary Report

Arch Derm Syphilol. 1950;61(4):673-675. doi:10.1001/archderm.1950.01530110139014
Abstract

Phenindamine (thephorin®) is an antihistaminic drug manufactured by Hoffmann-La Roche, Inc. It is a polycylic amine, the empiric formula of which is C19H19N (2-methyl-9-phenyl-2, 3, 4, 9 tetrahydro-1-pyridindene). This study is entirely a clinical one; therefore the chemical, pharmacologic and physiologic aspects of phenindamine will not be discussed. The ointment employed contained 5 per cent phenindamine hydrogen tartrate in carbowax® 1500. It is a white, odorless salve which is easily applied, does not stain and can be washed off with plain water. The treatment was used on patients of all ages and both sexes. The patients were engaged in the usual variety of occupations and showed the variations in personal hygiene commonly seen in private practice.

The cases used in this study were selected. Only those eruptions for which it was thought proper to use an ointment were chosen. The lesions were

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