Reports1 on the use of physiologically compatible fatty acids singly in the treatment of dermatophytoses have been uniformly encouraging. The application of fatty acids to dermatophytoses stems from the work of Peck and others.2 These authors found that concentrated sweat, by virtue of its propionic and caprylic acid content, is an efficient fungistatic agent and that preparations of these acids and their salts are effective clinically. Peck and Russ3 found a combination of propionates and caprylates to be more effective than either one alone, and their series of 124 treated patients established the fact that these compounds were exceptionally well tolerated. Therefore, propionate-caprylate ointment (ointment "sopronol" propionate-caprylates compound, a water-soluble ointment containing 12.3 per cent sodium propionate, 2.7 per cent propionic acid, 10 per cent sodium caprylate, 5 per cent zinc caprylate and 0.1 per cent dioctyl sodium sulfosuccinate) and powder (powder "sopronol" propionates-caprylate compound, a
BREWER WC. TREATMENT OF DERMATOPHYTOSES WITH PROPIONATE-CAPRYLATE MIXTURES. Arch Derm Syphilol. 1950;61(4):681–683. doi:10.1001/archderm.1950.01530110147018
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