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Article
May 1950

VESICULAR DARIER'S DISEASE (SO-CALLED BENIGN FAMILIAL PEMPHIGUS): A Variant of Darier's Disease

Arch Derm Syphilol. 1950;61(5):715-736. doi:10.1001/archderm.1950.01530120006001
Abstract

PELS AND GOODMAN1 in 1939 reported the case of a patient with Darier's disease in whom vesicle formation was a prominent feature. They stated that "this report of a case of Darier's disease was prompted by the unusual moisture and vesiculation, which were prominent features, and particularly by the confusion of the diagnosis with possible pemphigus vegetans." One month later Hailey and Hailey2 published an article under the title of "Familial Benign Chronic Pemphigus" in which 4 patients who had an apparently similar syndrome were described. Goodman3 in a letter in 1939 wrote:

The data presented by Drs. Hailey lead inescapably to the conclusion that they were dealing with Darier's disease of the rare vesicular and bullous type described by Dr. Pels and me in the aforementioned article. All the features which they described for their cases should maintain this diagnosis: namely, chronicity, familial occurrence, benignancy,

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