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Article
May 1950

LYMPHOBLASTOMA CUTIS: Report of a Case Treated with Nitrogen Mustard

Author Affiliations

JOLIET, ILL.; OKLAHOMA CITY

From the Departments of Internal Medicine and Dermatology and Syphilology of the University of Oklahoma School of Medicine and University Hospitals.

Arch Derm Syphilol. 1950;61(5):800-812. doi:10.1001/archderm.1950.01530120091008
Abstract

BECAUSE reports in the literature of the use of the nitrogen mustards in cases of cutaneous lymphoblastoma are few, we feel justified in reporting the accompanying case which has been of interest to us because of the dramatic changes brought about, both clinically and histologically, after the administration of methyl-bis (β-chloroethyl) amine.

Many pathologists now consider lymphoblastoma as a generic term in which many single entities are encompassed: lymphosarcoma, lymphatic leukemia, Hodgkin's disease, giant follicular lymphoma (Brill-Symmer disease), reticulum cell sarcoma and mycosis fungoides. That these are all closely related is attested by the frequency of observations of more than one pathologic picture in the same patient1 and the apparent metamorphosis from one type to another, as from Hodgkin's disease to giant reticulum cell sarcoma or from giant follicular lymphoma to reticulum cell sarcoma.1b

Many of these diseases have cutaneous manifestations. Leukemia cutis and mycosis fungoides

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