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May 1950

MAL DE MELEDA: Report of a Case and Results of Treatment with Vitamin A

Author Affiliations


From the Department of Dermatology, University of Illinois College of Medicine, Dr. F. E. Senear, Professor of Dermatology and Head of the Department.

Arch Derm Syphilol. 1950;61(5):820-823. doi:10.1001/archderm.1950.01530120111010

CASES of mal de Meleda are rarities in this country. Aside from those collected by Niles and Klumpp,1 no case reports could be found in an extensive search of the American literature. In reviewing the subject Niles and Klumpp set up certain criteria for differentiating mal de Meleda from the commoner Unna-Thost variety of keratoderma palmare et plantare hereditarium: (1) inheritance based on a recessive or irregular dominant gene rather than on a true dominant, (2) keratodermic involvement of other areas in addition to the palms and soles, (3) pronounced hyperhidrosis of the affected parts with maceration of the hyperkeratotic masses and consequent production of rancid odor and (4) the presence of a decidedly erythematous border about the keratodermic areas. Not all the 4 cases collected by Niles and Klumpp fulfilled these criteria, and in none was descent from an inhabitant of the island of Meleda proved.


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