In the June 1948 issue of the Archives of Dermatology and Syphilology Dr. David B. Morgan1 called attention to a sign that Dr. Charles C. Dennie associates with allergic tendencies. This sign is described as a definite wrinkle just beneath the margins of the lower eyelids which usually is present at birth or shortly thereafter and is retained throughout life. Dr. Morgan mentioned that this suggestive sign has not previously been reported in medical literature.
This wrinkle is found in many infants once the physician's attention is drawn to it and he starts looking for it. This wrinkle gets less conspicuous the older the child becomes, but on close examination it can be seen throughout most of the lifetime. In an occasional adult this wrinkle remains obvious. Those who have read Thomas Mann's "The Magic Mountain"2 may recall the detailed description he gave this wrinkle when describing
BARDACH K. A SUGGESTIVE SIGN OF ALLERGY. Arch Derm Syphilol. 1950;61(5):857. doi:10.1001/archderm.1950.01530120148017
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