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Article
May 1950

LOCALIZED AMYLOIDOSIS CUTIS ASSOCIATED WITH PSORIASIS IN SIBLINGS

Author Affiliations

NEW YORK

From the Skin and Cancer Unit and Department of Dermatology and Syphilology, the Post-Graduate Medical School of New York University-Bellevue Medical Center, Dr. Marion B. Sulzberger, director.

Arch Derm Syphilol. 1950;61(5):859-862. doi:10.1001/archderm.1950.01530120150019
Abstract

Although psoriasis is a common skin disease in which heredity is considered to be an important factor, nothing has been known about the familial incidence of the relatively rare localized amyloidosis cutis. The present report deals with 2 siblings who presented both amyloidosis cutis and psoriasis on the legs.

REPORT OF CASES

Case 1.—I. S., 64, a dentist of Russian-Jewish extraction with a history of psoriasis for thirty-five years, complained of severe itching on his legs for the last seven years.

Examination on Nov. 22, 1944, revealed numerous erythematous, infiltrated, scaly, papular lesions on the extensor surface of both legs with interspersed area sshowing pinhead-sized, firm, papular, yellow-brownish lesions. Biopsy of specimens from the papular lesions, clinically considered as characteristic of amyloidosis cutis, confirmed that diagnosis. The report of the microscopic changes (Dr. Wilbert Sachs) was as follows: "In the subepidermic region were several small masses taking a purplish

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