Although psoriasis is a common skin disease in which heredity is considered to be an important factor, nothing has been known about the familial incidence of the relatively rare localized amyloidosis cutis. The present report deals with 2 siblings who presented both amyloidosis cutis and psoriasis on the legs.
REPORT OF CASES
Case 1.—I. S., 64, a dentist of Russian-Jewish extraction with a history of psoriasis for thirty-five years, complained of severe itching on his legs for the last seven years.
Examination on Nov. 22, 1944, revealed numerous erythematous, infiltrated, scaly, papular lesions on the extensor surface of both legs with interspersed area sshowing pinhead-sized, firm, papular, yellow-brownish lesions. Biopsy of specimens from the papular lesions, clinically considered as characteristic of amyloidosis cutis, confirmed that diagnosis. The report of the microscopic changes (Dr. Wilbert Sachs) was as follows: "In the subepidermic region were several small masses taking a purplish
ISAAK L. LOCALIZED AMYLOIDOSIS CUTIS ASSOCIATED WITH PSORIASIS IN SIBLINGS. Arch Derm Syphilol. 1950;61(5):859–862. doi:10.1001/archderm.1950.01530120150019
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