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A Case for Diagnosis: (Porokeratosis? Kyrle's Disease?). Presented by Dr. U. W. Leavell, Dr. J. J. Stewart and Dr. J. G. Thomsen, from the service of Dr. H. N. Cole and Dr. J. R. Driver.
R. S., a Negro woman aged 35, has for the past four or five years noticed many small, firm elevations in the flexor folds of the palms and on the palmar surfaces of the fingers. The lesions develop slowly and without any subjective symptoms. A small, hard core, similar in color to the surrounding skin, develops in the center of each lesion; these cores eventually come out spontaneously or are picked out by the patient, leaving a small pit with an elevated border.
The patient had syphilis in 1934 and gonorrhea in 1946, both treated. Areas of depigmentation have been noted above and medial to the right eyebrow and elsewhere on the trunk since 1934.
Earl W. Netherton, George H. Curtis, Gerard A. DeOreo. CLEVELAND DERMATOLOGICAL SOCIETY. Arch Derm Syphilol. 1950;61(5):879–880. doi:10.1001/archderm.1950.01530120170026