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Article
June 1950

ACTION OF CORTISONE ON MESENCHYMAL TISSUES

Author Affiliations

NEW YORK

From the Departments of Medicine, Surgery and Surgical Pathology, Columbia University College of Physicians and Surgeons, and the Edward Daniels Faulkner Arthritis Clinic of the Presbyterian Hospital.

Arch Derm Syphilol. 1950;61(6):919-921. doi:10.1001/archderm.1950.01530130037009
Abstract

OF FUNDAMENTAL importance is knowledge of the mechanism of action of those adrenal hormones which act beneficially in disseminated lupus erythematosus and other diseases of tissues of mesenchymal origin. Two of the patients described in our clinical discussion1 showed failure to form granulation tissue while being treated, and 1 had prompt healing when treatment with pituitary adrenocorticotropic hormone (ACTH) was discontinued. In other patients, with rheumatoid arthritis, similar observations have been made.2 The question arose of whether ACTH and cortisone might not act by altering the host response to the disease, that is, by halting a connective tissue process which results in the various clinical entities of these diseases.

Accordingly, an experimental evaluation of the effect of various steroids on the connective tissues is going on in our laboratories. Preliminary data3 indicate that cortisone administered to rabbits exerts a profoundly inhibitory effect on

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