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June 1950


Author Affiliations

Fellow in Dermatology and Syphilology, Mayo Foundation ROCHESTER, MINN.

Arch Derm Syphilol. 1950;61(6):925-930. doi:10.1001/archderm.1950.01530130043011

DESPITE the fact that pityriasis rubra pilaris was first described almost a hundred years ago,1 there are still many gaps in knowledge of the clinical course, extracutaneous manifestations and pathogenesis of the disease. Our interest was recently drawn to this subject when we saw, within a relatively short time, 2 patients in whom a diagnosis of pityriasis rubra pilaris had been made, both of whom presented clinical evidence of concomitant neuromuscular disease. We felt, therefore, that a review of a larger group of cases of pityriasis rubra pilaris might shed further light on this interesting observation. This report represents a clinical analysis of 58 cases in which a diagnosis of pityriasis rubra pilaris was made at the Mayo Clinic.

The first reported treatment of this disease with vitamins was that of Pettler,2 who had 2 patients, both of whom had been on vitamin-

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