THE TERM "eosinophilic granuloma" usually refers to a specific bone lesion considered by some (particularly Jaffe and Lichtenstein1) to be the early monosymptomatic form of Hand-Schüller-Christian disease. This concept is well supported by Holm, Teilum and Christensen's2 report of 6 cases showing a gradual transition from the early solitary lesion to the picture of Hand-Schüller-Christian disease.
However the term "eosinophilic granuloma" has not been confined to this entity. It has been applied to other conditions, apparently different from Hand-Schüller-Christian disease. Curtis and Cawley3 reported the case of a girl whose condition was similar to a seborrheic dermatitis with small, red, discrete and coalescent papules on the buttocks and eroded patches in the mouth. In each axilla weeping, sharply demarcated erythematous papules were noted. Roentgenologic examination showed destructive lesions of a rib and the ilium. Biopsy specimens of the lesions of the skin
ADAMS P, KRAUS JE. EOSINOPHILIC GRANULOMA: An Unusual Case with Involvement of the Skin, Lungs and Kidneys. Arch Derm Syphilol. 1950;61(6):957–970. doi:10.1001/archderm.1950.01530130075014
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.