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July 1950

EOSINOPHILIC GRANULOMA OF THE SKIN: Report of Cases Representing the Two Different Diseases Described as Eosinophilic Granuloma

Author Affiliations


From the Department of Dermatology, Harvard Medical School, and the Dermatologic Service, Massachusetts General Hospital, Dr. Chester N. Frazier, chief.

Arch Derm Syphilol. 1950;62(1):85-96. doi:10.1001/archderm.1950.01530140089009

EOSINOPHILIC granuloma of the skin has been since 1946 a frequently discussed topic in the American dermatologic literature.1 At first a good deal of confusion prevailed since entirely different cutaneous lesions were described under this diagnosis; recently, however, it has become apparent that the cutaneous lesions described under the term eosinophilic granuloma can be divided into three groups, namely (1) cases associated with and identical in pathogenesis with eosinophilic granuloma of the bone, (2) cases characterized by torpid, asymptomatic, purplish patches on the face and (3) a heterogeneous group of cases having in common nothing but a large percentage of eosinophils in a granulomatous infiltrate.

The third group, on account of its varying etiology, does not deserve the diagnostic term eosinophilic granuloma. However, elimination of this group still leaves two entirely different diseases endowed with the same diagnostic term.

In this paper, 1 case of the first