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August 1950


Arch Derm Syphilol. 1950;62(2):314-318. doi:10.1001/archderm.1950.01530150136017

IN AN EARLIER paper, one of us (S. W. S.) reported1 on the use of a combination of an antihistaminic drug and penicillin in an attempt to decrease the allergic responses to the antibiotic. Crystalline potassium penicillin G was dissolved in an isotonic solution of sodium chloride to which had been added 5 mg. per cubic centimeter of doxylamine ( decapryn® ) succinate (2- [α- (2-dimethylaminoethoxy)-α-methylbenzyl] pyridine succinate). Each cubic centimeter of this preparation contained 100,000 units of penicillin and 5 mg. of the antihistaminic drug. In a series of 292 patients, the reaction rate with the use of this doxylamine-penicillin mixture was 2.4 per cent, while in 400 control patients receiving the same aqueous crystalline penicillin alone, the rate was 6.5 per cent. As far as could be determined, the addition of the antihistaminic drug caused no loss in the efficacy of the penicillin