The search for an antihistaminic agent has been most intense in the past few years. At the time of writing there are in the neighborhood of fifteen different preparations on the market, this situation giving an indication of the amount of work that has been done by individual laboratories. However, the preponderance of research is directed toward finding a chemical agent which will combat or compete with the effect of histamine regardless of the shock organ, be it the bronchi, the nasal mucosa, the skin or another. That there might be physical means of releasing or forming antihistaminic substances in the skin seemed plausible after the observation of a number of cases of asthmatic episodes (and other conditions in which a histamine action is probable) in which the condition was relieved and stayed relieved for months, after indirect or general radiation of several areas of skin surface with grenz rays.
BUCKY G, BLANK F, DISTELHEIM IH. INFLUENCE OF GRENZ RAYS ON HISTAMINE-INDUCED MANIFESTATIONS. Arch Derm Syphilol. 1950;62(2):319–322. doi:10.1001/archderm.1950.01530150141018
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