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September 1950

INDUCED SENSITIZATION TO CERTIFIED DYE: Hypersensitivity Manifested on Sixth Exposure to Commercial Patch Testing Solutions

Author Affiliations


From the Department of Dermatology and Syphilology, University of Pennsylvania School of Medicine, Donald M. Pillsbury, M.D., director.

Arch Derm Syphilol. 1950;62(3):418-421. doi:10.1001/archderm.1950.01530160072011

SOLUTIONS of plant oleoresins prepared by ether extraction and dilution with 9 parts of acetone by volume have long been used for routine patch testing.1 Such preparations are available commercially,2 with green dye added to mark the site of the test on the skin. On the basis of a report of a single case of sensitivity to the green dye in 1941, a change to a certified dye was made by the manufacturer. The desired green color is obtained by the use of two dyes manufactured by National Aniline and Chemical Company, D. & C. Green No. 6 and F. D. & C. Yellow No. 3. The case reported herewith is apparently an instance of induced sensitivity to these certified dyes.3


C. D., a white woman aged 49, was seen in July 1947 because of a recurrent, seasonal, eczematous eruption of eight

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