In a recent article, Bluefarb1 reported the occurrence of comedos following roentgen irradiation of epitheliomas. These comedos involved the previously normal skin in and slightly beyond the irradiated patch. Ronchese2 later reported his observations on the same subject. I should like to add my own.
Bluefarb considered this occurrence a rare one, having observed it only once in several hundred cases of epithelioma treated by roentgen radiations. Ronchese considered it not at all unusual and thought that it should occur in practically every case in which the pilosebaceous apparatus was normally developed. I concur with Ronchese on its incidence but not on the mechanism of its formation. He thought the comedo due to a cicatrizing stricture of the gland's outlet with a resulting blockade of sebum. Bluefarb considered it due to a compensatory hypertrophy of the pilosebaceous apparatus. I believe the process to be one of simple stagnation,
HARTMAN MS. POSTRADIATION COMEDOS. Arch Derm Syphilol. 1950;62(3):440–441. doi:10.1001/archderm.1950.01530160094017
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