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October 1950


AMA Arch Derm Syphilol. 1950;62(4):556-561. doi:10.1001/archderm.1950.01530170082010

Lesions of leukemia cutis occur more frequently in lymphogenous leukemia than in myelogenous or monocytic leukemia. Cutaneous lesions may be present in the acute, chronic and so-called aleukemic phases.1 There is much variation in their size, number, distribution and other characteristics. In lymphogenous leukemia the cutaneous lesions have been observed to appear and disappear consistently with the fluctuations in the white blood cell count2; on the other hand, a case has been cited in which the cutaneous tumors continued to appear and became pronounced despite the fall of the white blood cell count to normal ranges. The tumors are usually sensitive to radiation.

Although the appearance of tumors is usually considered of grave prognostic import, many occur from one to several years before death. They are prone to occur about the head. Cleland3 has expressed the opinion that local infiltrations are metastases, and he called attention to