THE EFFECTS of specific vitamins on various skin diseases have been noted by many observers, and the effects of vitamins on the pilosebaceous apparatus have been extensively investigated. Sulzberger and Wolf,1 in discussing the treatment of acne vulgaris, stated that "the basis of the acne process may be directly attributable to the local effects of the sex hormones on the pilosebaceous apparatus. However, despite the astonishingly rapid progress in endocrinology, the hormonal treatment of acne vulgaris has as yet proved of little value."
The role of vitamin A in the treatment of acne has received wide study following the brilliant report of Frazier and Hu2 in 1936. Many workers have reported on the beneficial effects of large doses of vitamin A in oil solution. Straumfjord3 reported that a supplement of 100,000 international units of vitamin A either cured or decidedly improved the condition of 79
KLINE PR. ROLE OF PARENTERAL MULTIVITAMIN THERAPY IN THE TREATMENT OF ACNE. AMA Arch Derm Syphilol. 1950;62(5):661–665. doi:10.1001/archderm.1950.01530180050010
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