Sarcoidosis may involve the skin primarily with a variety of lesions and in addition affect other tissues and systems. Thus, the lymph glands, bones and various viscera may be involved. The debate about the etiology of this disease has been warm and extensive, with the clearest overtones heard with regard to a tuberculous cause.
The majority of subjects react negatively to tuberculin even in high concentration, and most of the minority show weakly positive reactions. It has been held that a special immunologic state in sarcoidosis decreases or entirely prevents the positive reaction to tuberculin which otherwise would be present to indicate the underlying tuberculous infection.
When persons with negative reactions to tuberculin, who presumably, therefore, are free from past or present tuberculous infection, are inoculated with BCG vaccine, 90 per cent manifest positive reactions in two weeks and about 100 per cent do so in four weeks.
CORNBLEET T. BCG VACCINATION IN SARCOIDOSIS: Preliminary Report. AMA Arch Derm Syphilol. 1950;62(5):697–698. doi:10.1001/archderm.1950.01530180086018
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