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Experience in one case of extensive and long-standing acne varioliformis suggested that local aureomycin therapy may be effective in managing this disease. Three other patients for whom this diagnosis had been made clinically and whose condition was being managed or controlled satisfactorily on topical ammoniated mercury therapy (5 per cent) were given a trial with aureomycin ointment. They discontinued mercury therapy until recurrence was noted and then compared the efficiency of aureomycin ointment with that of the mercury ointment on previous trials. The response or clearing of lesions under treatment with aureomycin ointment was as good as under mercury ointment therapy. In another case in which mercury ointment was only partially effective in managing or controlling the eruption, aureomycin ointment seemed to be more effective and brought the eruption promptly under control.
Evaluation of a drug in treatment of a disease in which there are spontaneous remissions is
J. B. HOWELL. AUREOMYCIN OINTMENT IN ACNE VARIOLIFORMIS. AMA Arch Derm Syphilol. 1950;62(5):705–706. doi:10.1001/archderm.1950.01530180094023