Baker and Whitaker1 reported inhibition of growth of hair follicles, atrophic changes in epidermis, dermal changes and reduction in sebaceous glands in rats following direct application of adrenal cortex preparations to the skin. Changes were similar to those seen after parenteral injection of adrenocorticosterone. The ability to produce this effect was attributed to the 11-oxysteroids from the adrenal cortex.
In this present study, five human subjects, one female and 4 male, applied 0.6 cc. of adrenal cortex extract2 in 25 per cent alcohol to an area 30 mm. square on the ventral surface of the thigh daily, using as a control 25 per cent alcohol on the corresponding area on the other leg. In two of the subjects the areas were shaved. The experiment lasted 14 weeks in the males but was ended in the other case at 9 weeks. In all cases the number of hairs in
GRANT R, CORNBLEET T, GROSSMAN MI. INFLUENCE OF LOCAL APPLICATION OF ADRENAL CORTICAL EXTRACT ON HAIR GROWTH IN THE HUMAN. AMA Arch Derm Syphilol. 1950;62(5):717–718. doi:https://doi.org/10.1001/archderm.1950.01530180106031
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