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December 1950


AMA Arch Derm Syphilol. 1950;62(6):771-785. doi:10.1001/archderm.1950.01530190003001

IN JANUARY 1948 Hargraves and his associates1 first reported observations on certain bone marrow elements to which they gave the name L. E cells and tart cells. In September of that same year Haserick and Sundberg2 reported further observations on the L. E. cell. In February 1949 Sundberg and Lick3 reported for the first time the observation of the L. E. cell in peripheral blood, and this observation was confirmed by Hargraves4 in April 1949. In May 1949 Klemperer and his co-workers5 reported the observation of hematoxylin-staining bodies comparable to L. E. bodies in 31 autopsies of acute disseminate lupus erythematosus patients. In July 1949 Haserick and Bortz6 reported that they had produced L. E. cells by mixing the plasma of acute disseminate lupus erythematosus patients and normal sternal marrow. In April 1950 Moffatt, Barnes and Weiss7 described a method of producing

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