SINCE warts do not always respond to the simple and usually effective measures directed against them, further therapeutic experimentation may rightly be attempted, particularly for periungual warts and large or numerous plantar warts or plantar warts persisting after radiotherapy, each of which condition is likely to resist treatment. Dermatological attention was redirected to the use of formaldehyde against plantar warts by Sydney Thomson1 in 1943, but the drug had been used previously, though its history is not clear. It is mentioned rather casually in foreign general reviews of therapy,2 and American dermatologists trained abroad have long used it in this country, especially against condylomata acuminata.3 Caro4 mentioned it as an old drug but a useful treatment for periungual warts. Thomson's method was the daily soaking of plantar warts in a 3 per cent aqueous solution of formalin. For a time one of us used 3
LYNCH FW, KARON IM. FORMALDEHYDE IN THE TREATMENT OF WARTS. AMA Arch Derm Syphilol. 1950;62(6):803–813. doi:10.1001/archderm.1950.01530190037003
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