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Histoplasmosis Involving Tongue, Larynx, Lungs and Probably Liver. Presented by Dr. Franz Blumenthal and Dermatological Staff of Wayne County General Hospital, Eloise, Mich.
J. G., a 63 year old white man, acquired an ulcer of the tongue in December 1948. Later he became hoarse and lost 7 pounds (3 Kg.). When first seen he presented a deep ulcer (1 by 1.5 cm.) on the anterior right side of the tongue. The liver was felt 8 cm. below the right costal margin. A biopsy of the tongue showed chronic granulomatous inflammation and bodies resembling Histoplasma capsulatum, and a liver biopsy showed miliary granulomas but no micro-organisms. H. capsulatum was isolated in cultures from tongue, stools and bronchial secretions. No acid-fast bacilli were found on repeated examinations. Guinea pig inoculation showed reticulum cell hyperplasia of the spleen.
Treatment consisted of the administration of copper sulfate, ¼ grain (15 mg.) three times
Stiles F, Pinkus H. DETROIT DERMATOLOGICAL SOCIETY. AMA Arch Derm Syphilol. 1950;62(6):935–938. doi:10.1001/archderm.1950.01530190169019
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