A TOTAL of 631 pregnant women delivered during 1948 and 1949 were treated with penicillin either before or during pregnancy at the Social Hygiene Clinic of the Detroit Department of Health. Various schedules of treatment were used. Most patients received ambulatory treatment with repository penicillin in total doses of 3,600,000, 4,800,000 or 9,600,000 units. Some were given aqueous penicillin G totaling 2,400,000 or 4,800,000 units, and another group received 3,000,000 units of repository penicillin with or without oxophenarsine hydrochloride and a bismuth preparation during 10 days of hospitalization. No appreciable difference in the effectiveness of these schedules was noted, and no separate analysis according to the schedule employed will therefore be made. Data on every pregnant woman who was treated with penicillin in the clinic and delivered during this two year period are included.
The majority of these women were delivered at the Herman Kiefer Hospital operated by the Detroit
SHAFFER LW, COURVILLE CJ. EFFECTIVENESS OF PENICILLIN IN THE PREVENTION OF CONGENITAL SYPHILIS. AMA Arch Derm Syphilol. 1951;63(1):91–103. doi:10.1001/archderm.1951.01570010094008
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