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February 1951

HYALURONIDASE ACTION IN NORMAL AND IN ROENTGEN-IRRADIATED RABBIT SKIN

AMA Arch Derm Syphilol. 1951;63(2):191-199. doi:10.1001/archderm.1951.01570020025003
Abstract

IN AN INVESTIGATION of the biologic effect of roentgen therapy, hyaluronidase action has been studied in normal and in roentgen-irradiated rabbit skin. Roentgen therapy administered in vitro has been reported as having no effect on hyaluronidase activity.1 On the other hand, roentgen irradiation may inactivate purified preparation of hyaluronidase.2 This report concerns a comparative study of the spreading activity of hyaluronidase3 in normal and in irradiated living tissue.

Hyaluronidase is probably identical with "spreading factor," which was first described by Duran-Reynals4 in 1929. Meyer5 pointed out that hyaluronic acid is one of the mucopolysaccharides which act to hold cells together in a jelly-like matrix, to block the spread of foreign matter and to hold water in interstitial spaces. It probably participates in the formation of barriers against infection and in the exchange of water, electrolytes and metabolites. The enzyme hyaluronidase is capable of hydrolyzing or

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