The use of vitamin D in the treatment of psoriasis has been advocated by Krafka1 and Ceder and Zon2 after the encouraging results they obtained. Other authors, however, reported equivocal or unimpressive results (Wright,3 Pascher and co-workers4 and Clarke5).
One of the drawbacks of using vitamin D has been the possibility of toxic reactions. Recently, refinements of production have eliminated some of the toxic substances responsible for undesirable side effects.
In an attempt to evaluate the effects of a modern preparation of vitamin D2, a limited number of unselected patients with psoriasis were treated with a sterile solution of persic oil and ether containing 600,000 U. S. P. units of crystalline vitamin D2 per cubic centimeter.6
Prior to treatment, the history of each patient was taken. A complete physical examination was performed, after which a skin specimen was taken for biopsy.
M. F. ALLENDE, F. G. NOVY, J. H. BENNETT. VITAMIN D2 IN THE TREATMENT OF PSORIASIS. AMA Arch Derm Syphilol. 1951;63(2):254–255. doi:10.1001/archderm.1951.01570020088013