Danna1 and Sulzberger and Baer2 have favorably commented on the use of antibiotic solutions in the treatment of cystic and indurated acne. The use of 5 per cent sulfathiazole sodium seems to give faster and a better percentage of good results. It is my impression that the high pH of the sulfathiazole sodium has probably helped increase the effectiveness of this method over the use of penicillin.
I began the employment of the technic used in 1942. Best results seem to be obtained by the injection of 5 per cent sulfathiazole sodium directly into the wall of the acne cyst. Great pressure will cause an extrusion of the cyst plug, and results are usually not very effective. The injection of penicillin, which was used almost exclusively during 1945 and 1946, did not in my hands give as effective results as the injection of the aqueous solution of
REICHES AJ. SULFATHIAZOLE SODIUM TREATMENT OF CYSTIC AND INDURATED ACNE LESIONS. AMA Arch Derm Syphilol. 1951;63(2):265–266. doi:10.1001/archderm.1951.01570020099019
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