The multiplicity of therapeutic measures suggested for acne vulgaris, the commonest cutaneous disease of adolescence, indicates the lack of specificity of any of them. Sulfur, however, is apparently the most effective local remedy.1 Drying of the skin, some exfoliation and antiseptic action are expected from the use of sulfur preparations.The etiology of acne is not clear. Heredity,2 endocrine disturbances, particularly of the thyroid and pituitary glands,3 digestive disturbances,4 disturbances in the water balance,5 higher activity of the parasympathetic nervous system,6 and excessive intake of fat7 and carbohydrates are factors most commonly reported as possibly bearing on the etiology of acne. However, there is much evidence that the last mentioned does not play an important role.8In view of the prominent position occupied by sulfur in the therapy of acne, a preparation of sulfur known as dermasulf® (polythionic acid preparation)9 was utilized in the
FINNERUD CW, RIDDELL JM. POLYTHIONIC ACID IN THE THERAPY OF ACNE VULGARIS AND SEBORRHEIC DERMATITIS. AMA Arch Derm Syphilol. 1951;63(3):373–375. doi:10.1001/archderm.1951.01570030087010
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