Since H. Géber1 in 1921 first demonstrated menstrual urticaria comparatively few case reports have appeared in the literature. In 1930 H. Géber2 reported successful treatment of the disorder by injections of autoserum of the menstrual epoch. Zondek and Bromberg3 tested for allergic sensitivity, using steroids in oil. They obtained a high percentage of false positive reactions due to the oil and later avoided this result by giving the injections deeper. Phillips,4 reporting on two years' experience with water-soluble gonadotropins, found 107 positive reactions to them in allergic women. Attempted desensitization by injections of synapoidin® (a combination of chorionic gonadotropin from human pregnancy urine and follicle-stimulating hormone from anterior pituitary glands, biologically standardized to contain 15 synergy rat units per cubic centimeter) was of doubtful service in three cases of urticaria. In 1948 Baer, Witten and Allen5 reported testing 165 cases. In 30 cases with a definite clinical relationship to genital function four positive reactions were obtained, and in two cases desensitization was accomplished by injections.
GUY WH, JACOB FM, GUY WB. SEX HORMONE SENSITIZATION (CORPUS LUTEUM). AMA Arch Derm Syphilol. 1951;63(3):377–378. doi:10.1001/archderm.1951.01570030091012
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