IN A RECENT publication1 our experiences in the treatment of neurosyphilis with penicillin combined with artificial fever were reported and the reasons for combining these two methods of therapy were stated.
Excellent therapeutic results in the treatment of neurosyphilis with penicillin alone have been reported recently by Stokes and his co-workers.2 Curtis and associates3 concluded that in neurosyphilis the results of therapy with penicillin combined with malaria were no better than those with penicillin alone. These studies seem to indicate that fever therapy is not necessary in the treatment of neurosyphilis. We believe, however, that the ultimate efficacy of any given treatment method for neurosyphilis cannot be stated until such a method has been studied for many years. Therefore, we are persisting in the study of the fever plus penicillin method of therapy for neurosyphilis. We hope that in this way a more accurate conclusion may be
EPSTEIN NN, ALLEN JR. TREATMENT OF NEUROSYPHILIS WITH PENICILLIN COMBINED WITH ARTIFICIAL FEVER THERAPY: II. Further Observations. AMA Arch Derm Syphilol. 1951;63(4):419–425. doi:10.1001/archderm.1951.01570040013002
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