THE USEFULNESS of penicillin in the treatment of cardiovascular syphilis is being evaluated by various groups. Several reports1 of investigations using different schedules and employing varying total doses show that penicillin in various vehicles rarely causes reactions necessitating cessation of treatment in this group of patients. A few articles show important follow-up observations over extended periods, the longest being 1,243 days.2 Caution against starting any treatment with penicillin before heavy metals have been used is emphasized by some authors3 and disregarded by others. Some fatalities as well as instances of anginal and precordial pain concomitant with penicillin therapy in cardiovascular syphilis have been reported4 and undoubtedly have led to hesitation in the use of the drug in similar cases.
In January 1947 we started treating patients having syphilitic heart disease with aqueous penicillin G intramuscularly, using a gradually increasing dosage schedule to see whether this manner of administration of penicillin would prevent the buga
JOHNSON SAM, SHAPIRO HH. OBSERVATIONS ON TREATMENT OF CARDIOVASCULAR SYSTEM SYPHILIS WITH AQUEOUS PENICILLIN G. AMA Arch Derm Syphilol. 1951;63(4):426–432. doi:10.1001/archderm.1951.01570040020003
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