A PRELIMINARY report1 made on Nov. 12, 1949, based on a study of 27 persons with dark field-positive syphilis, concluded that aureomycin (1) causes an initial satisfactory decline in the serologic titer, (2) rids syphilis lesions of surface spirochetes in an average time of 39 hours and, administered orally in the high dosage schedule described, (3) causes a mild to moderate degree of gastrointestinal disturbance in almost 100 per cent of the patients.
The present study is of 67 patients with dark field-positive syphilis, including those in the preliminary report. The disease of 62 patients was diagnosed as secondary, of 2 as seropositive primary and of 3 as seronegative primary syphilis. All patients were previously untreated for syphilis.
The distribution of these patients by race, sex and age is indicated in table 1. The age range for the group was 17 to 43, with a median age of 24
RODRIQUEZ J, PLOTKE F, WEINSTEIN S, HARRIS WW. AUREOMYCIN AND ITS EFFECT IN EARLY SYPHILIS: Progress Report. AMA Arch Derm Syphilol. 1951;63(4):433–439. doi:10.1001/archderm.1951.01570040027004
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: