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Article
April 1951

REPORT OF A CASE OF LUPUS VULGARIS TREATED WITH STREPTOMYCIN

Author Affiliations

MEMPHIS, TENN.

From the Tuberculosis Section, Medical Service, the Veterans Administration Medical Teaching Group, Kennedy Hospital.

AMA Arch Derm Syphilol. 1951;63(4):469-473. doi:10.1001/archderm.1951.01570040063010
Abstract

CONSIDERABLE information has been published recently concerning the value of calciferol in the treatment of lupus vulgaris. Though streptomycin is known to be of considerable value in the treatment of tuberculosis of various organs of the body, a conscientious review of the literature revealed only one report of its use alone in the treatment of lupus vulgaris. Several authors have commented on the probability of its value in therapy, and one writer reports on its use in conjunction with calciferol.

In treatment with calciferol some writers reported an early exacerbation of the lupus lesions, which became swollen and angry looking, with ulcers that broke down spontaneously, followed by improvement. Raised, firm plaques responded well to calciferol therapy, but isolated areas in fibrous patches did not do so well. Disadvantages of the therapy were risk of toxic effects, hypervitaminosis, renal calculi and damage, and dissemination of tuberculous disease during the initial

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