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Article
May 1951

TREATMENT OF CUTANEOUS TUBERCULOSIS WITH LOCAL INJECTIONS OF STREPTOMYCIN

AMA Arch Derm Syphilol. 1951;63(5):597-605. doi:10.1001/archderm.1951.01570050055006
Abstract

ONE of cutaneous tuberculosis, cure being rare. Recently, however, the apparent cure of this condition in remarkably short periods has been achieved by infusion of streptomycin, intracaine® (beta-diethylaminoethyl para-ethoxy benzoate) hydrochloride and epinephrine into tuberculous lesions and surrounding areas of the skin. I have found that in this manner streptomycin can be used much more effectively and without the side effects encountered with other parenteral methods. The treatment leaves little scar tissue, does not require maintenance of streptomycin levels and can be carried out in the office. The primary aim of this report is twofold: (1) to demonstrate a practical method whereby cutaneous tuberculosis may be healed clinically and (2) to formulate rational, consistent attitudes and approaches to the problem of tuberculosis of the skin.

FACTORS IN STREPTOMYCIN THERAPY  In order to determine the dose, duration of treatment and method of administration of streptomycin, certain factors have to be considered,

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