THE RENEWED interest in syphilotherapy that began with Ehrlich, who at first believed that arsphenamine could eradicate syphilis with one injection, has continued with the hope that some such quick cure could be found. Pollitzer1 and, in more recent years, Chargin2 believed that by giving arsenical treatments daily for a few days or by administering large doses in a slow but continuous drip method one could obtain a cure. However, serious reactions due to intensive arsenical therapy were reported, and in a few instances death occurred.
When Mahoney and co-workers3 reported that injections of penicillin were curative and caused no reactions, it was felt that the ultimate safe cure had been found. It was soon noted that the 600,000 units originally used was not sufficient for cure, and relapses were frequent. Even with the dose increased to 1,200,000 and 2,400,000 units, too many recurrences were noted. It
ROBINSON HM, ROBINSON HM. ANTIBIOTICS IN EARLY SYPHILIS AND IN SYPHILIS COMPLICATED BY PREGNANCY. AMA Arch Derm Syphilol. 1951;63(6):687–701. doi:10.1001/archderm.1951.01570060015002
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