IN A PREVIOUS report,1 preliminary studies concerning the nature of autoeczematization were described. Patients with autoeczematization secondary to various types of eczematous dermatoses were tested intradermally with autogenous extracts of scale, leukocytes and blood plasma. Positive reactions to scale extracts were obtained in a significant proportion of cases. The results of skin testing with the various substances indicated that autoeczematization is a true allergic reaction and that the antigen responsible for the distal eczematous process is apparently a water-soluble fraction of epidermal cells. The development of doubtful reactions to leukocytes in a few instances raised the question as to their possible role in the transportation of the epidermal antigen from the primary eczematous focus. As a result of this preliminary study it was felt that the specificity of the scale antigen should be confirmed, its mode of transportation determined and the importance of the eosinophil in this process evaluated.