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Article
August 1951

SQUAMOUS-CELL EPITHELIOMA THAT SIMULATES SARCOMA

Author Affiliations

ROCHESTER, MINN.

AMA Arch Derm Syphilol. 1951;64(2):149-158. doi:10.1001/archderm.1951.01570080033005
Abstract

WE WISH to report on a group of 40 Mayo Clinic cases in which the pathologic diagnosis was squamous-cell epithelioma of the skin with features of sarcoma. This series does not include any cases of epithelioma on the lip in which the pathologic picture simulated sarcoma, of which we have seen several instances. In the majority of the cases the histopathologic changes simulated those of fibrosarcoma, although in a few there were observations suggestive of other types of sarcoma, hemangioendothelioma, and nonmelanotic melanoepithelioma. The clinical appear- ance of this group of neoplasms is not diagnostic per se, and frequently the lesions may present features of a granuloma rather than features of an epithelial neoplasm (Fig. 1). In addition to the 40 cases encountered at the clinic, one of us (H. M.) has seen 12 additional specimens of tissue sent in from the outside which revealed the features of squamous-cell epithelioma that

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