Brocq1 in 1894 introduced the term "fixed drug eruption" to denote an unusual form of eruption produced by the ingestion of antipyrine. The chief characteristic of this eruption was that it recurred in the primarily affected area each time antipyrine was taken. The manifestations were erythematous, pigmentary or vesiculobullous plaques sometimes involving the mucosal orifices. The term "fixed"2 has since been extended to various types of eruptions, such as urticarial, erythematous or eczematous ones, that reappear in the parent site as a result of the use of a drug. J. Jadassohn3 extended the term "fixed" to include extracutaneous effects from drugs characterized by the recurrence of symptoms in the original sites in tissues other than the skin or mucous membranes. The case reported below is an example of a typical fixed drug eruption and an unusual extracutaneous effect, an epididymitis, due to the ingestion of antipyrine.
REPORT OF A CASE
McCULLOCH H, ZELIGMAN I. FIXED DRUG ERUPTION AND EPIDIDYMITIS DUE TO ANTIPYRINE. AMA Arch Derm Syphilol. 1951;64(2):198–199. doi:10.1001/archderm.1951.01570080082013
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