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Benign Familial Pemphigus Improved by Aureomycin. Presented by Dr. B. D. Erger.
D. R., a man aged 30, had an eruption since 1941. It occurred on the neck, arms, axillas, penis, scrotum and perianal area at various times and, occasionally, at all the sites mentioned simultaneously. The patient averred that he had never been entirely free of the eruption since its onset.When first seen in 1948 he presented exudative, superficial, crusting, eroded, circinate and gyrate plaques on the neck and in the axillas. The scrotum, penis and perineum were involved in a similar continuous process which was painful and disabling.Histopathological examination revealed the following: There was splitting of the epithelial layers, leaving an irregular clear space within the epithelial layer and the germinal layer intact. Some cells surrounding the clear space had irregular, spindle-shaped pyknotic nuclei, and the cytoplasm of these cells was often scanty and denser than
I. N. Holtzman, S. I. Greenberg. BROOKLYN DERMATOLOGICAL SOCIETY. AMA Arch Derm Syphilol. 1951;64(2):232–233. doi:10.1001/archderm.1951.01570080116028