Until recently periarteritis nodosa has been considered a rare disease. The number of cases on record has increased considerably. This apparent increase has resulted from the attention clinicians and pathologists have given the disease. The dermatologist is in an especially good position to diagnose periarteritis nodosa when it shows itself in the skin.
Cutaneous manifestations vary from simple erythema to erythema multiforme or erythema nodosum, urticaria, and even purpura. Subcutaneous nodules develop which occasionally are followed by vesicular, pustular, or necrotic lesions, depending on the size of the vessel involved and the situation and depth of the nodule. Lesions may be single or multiple. They occur as nodules along the course of a superficial artery. The lesions are usually very painful on pressure. Systemic manifestations are multiple and protean and may pertain to any organ of the body and, again, are dependent on the amount of vascular damage done. The
CARRICK L, HEIDE ECV. PERIARTERITIS NODOSA: Report on a Patient Treated with Paraaminosalicylic Acid. AMA Arch Derm Syphilol. 1951;64(3):359–362. doi:10.1001/archderm.1951.01570090106014
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