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September 1951


AMA Arch Derm Syphilol. 1951;64(3):362-364. doi:10.1001/archderm.1951.01570090109015

Generalized or localized pruritus is a symptom frequently encountered in medical and dermatologic practice. It is evident from the large number of therapeutic remedies which have been applied both locally and systemically in pruritus that no single means of controlling itching in the majority of these cases is available.

Within the past two years several reports1 have appeared which have indicated that the parenteral administration of adenylic acid (adenosinemonophosphate) may be of value in the relief of pruritus from many different causes. On the basis of these results, the suggestion has been made1b that there may be a fundamental mechanism for pruritus which involves the metabolism of adenylic acid.

Recently we have had an opportunity to observe the effect of adenylic acid and a related compound, adenosinetriphosphate, on a series of patients with pruritus originating from a variety of conditions, chiefly dermatologic. In general, the results of these

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