[Skip to Navigation]
September 1951


Author Affiliations


AMA Arch Derm Syphilol. 1951;64(3):366-369. doi:10.1001/archderm.1951.01570090113017

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Although the exact mechanisms involved in the causation of primary depigmentation of the skin are not known, the hypothesis of the participation of the nervous system has been considered by many writers, on the basis of indirect clinical evidence. Some cases of vitiligo show absolute (mirror image) bilateral symmetry. This distribution is difficult to explain except on the basis of central nervous system participation, that is, segmental-dermatomal arrangement. However, since the involvement of any one dermatome is usually very incomplete, the fact of dermatomal involvement has not been readily proved. The case reported here brings no final proof but does present what appears to be strong clinical evidence to support the idea that the central nervous system plays a role in the pathogenesis of vitiligo.

REPORT OF A CASE  A 28-year-old white American shoemaker, C. D., was first seen in October, 1949, presenting a large area of pigment loss involving

First Page Preview View Large
First page PDF preview
First page PDF preview
Add or change institution